SURPASS: evaluating the next-generation of SPEAR T-cell therapy

admin_vjr_user — Sat, 03 Jul 2021 11:01:08 +0000

Jo Brewer, PhD, Adaptimmune, Philadelphia, PA, describes the ongoing Phase I SURPASS trial (NCT04044859), which is assessing the safety and efficacy of ADP-A2M4CD8 in HLA-A2+ subjects with MAGE-A4 positive tumors. ADP-A2M4CD8 is a next-generation therapy and is differentiated from ADP-A2M4 therapy by the expression of a CD8-alpha co-receptor alongside the engineered TCR that targets MAGE-A4. This increases anti-tumor activity by leveraging CD4 cells into CD8+ killer or cytotoxic T-cells that target the tumor cells. In addition, the CD4 cells recruit other immune cells such as dendritic cells, which results in broader immune response to tackle the tumor. This interview took place during the Cell & Gene Meeting on the Mediterranean 2021 virtual conference.

Adaptimmune: SPEAR T-cells

admin_vjr_user — Tue, 03 Nov 2020 17:39:49 +0000

TCR T-cell therapies (SPEAR T-cells) hold the potential to treat a wide range of cancers. In this video, Helen Tayton-Martin, Chief Business Officer, Adaptimmune, Oxford, UK. discusses the SPEAR T-cells currently under development with Adaptimmune. Dr Taytor-Martin goes on to discuss Adaptimmune’s partnership with GlaxoSmithKline (GSK) and recent advances such as the SURPASS trial (NCT04044859) which investigated ADP-A2M4CD8 in HLA-A2+ subjects with MAGE-A4 positive tumors. This interview took place during the 2020 Meeting on the Mesa congress.

ADP-A2M4CD8 – VJRegenMed

SURPASS: evaluating the next-generation of SPEAR T-cell therapy

Adaptimmune: SPEAR T-cells