Developing iPSC-derived MSCs for therapeutic purposes

Simon Ng — Wed, 20 Oct 2021 17:41:42 +0000

Miguel Forte, MD, PhD, Bone Therapeutics SA, Gosselies, Belgium, discusses the recently announced research partnership between Bone Therapeutics and Implant Therapeutics, which aims to drive the development of hypoimmunogenic induced pluripotent stem cell (iPSC)-derived mesenchymal stromal cell (MSC)-based therapies for various indications. Dr Forte explains that the implementation of iPSC technology offers the potential to optimize the effects of current MSC-based therapies such as ALLOB, an allogeneic MSC-based cell therapy platform being investigated for bone regeneration in orthopedic indications. This interview took place at the Advanced Therapies Congress & Expo 2021.

Off-the-shelf cell therapy for bone indications: ALLOB & JTA-004

admin_vjr_user — Thu, 24 Jun 2021 17:15:41 +0000

Miguel Forte, MD, PhD, Bone Therapeutics SA, Gosselies, Belgium describes ongoing research investigating allogeneic mesenchymal stromal cell (MSC)-derived osteoblastic cells (ALLOB) for the formation of bone in orthopedic conditions. The safety and efficacy of ALLOB has been tested in patients with degenerative disc disease (NCT02205138) and long bone fractures (NCT02020590), and its impact in tibial fractures is being evaluated in the ongoing Phase IIb ALLOB-TF2 trial (NCT04432389). Dr Forte also describes JTA-004, an intra-articular injectable currently being investigated in patients with knee osteoarthritis (NCT04333160), as well as plans to expand their MSC platform into immunomodulatory conditions. This interview took place during the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021.

ALLOB – VJRegenMed

Developing iPSC-derived MSCs for therapeutic purposes

Off-the-shelf cell therapy for bone indications: ALLOB & JTA-004