CAR-T vs. BiTEs in B-cell malignancies

Marta Palhas — Fri, 26 Feb 2021 14:08:22 +0000

Marion Subklewe, MD, LMU Hospital Munich, Munich, Germany, compares CAR T-cells to bispecific T-cell engagers (BiTEs). Firstly, Prof. Subklewe highlights that there are no randomized trials in any disease comparing CAR T-cells to BiTEs. Different parameters can be compared between CAR T-cells and BiTEs, including construct design, manufacturing, and production time. Additionally, data from clinical trials can provide insights into aspects such as safety and efficacy. Compared to CAR-T therapies, the BiTE platform provides an off-the-shelf product with a high safety profile, which are significant advantages. In the future, predictive biomarkers are needed to stratify patients to the safest and most successful treatment option. This interview took place during the 3rd European CAR T-cell Meeting.

The challenges of CAR T-cell therapy for pediatric B-ALL

Marta Palhas — Fri, 26 Feb 2021 14:08:21 +0000

Sara Ghorashian, PhD, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK, outlines the challenges associated with CAR T-cell therapy for pediatric B-cell acute lymphoblastic leukemia (ALL). Discovering the best treatment phasing with other immunotherapies, such as blinatumomab and inotuzumab, improving the toxicity profile, and CAR T-cell persistence are some of the remaining challenges. In addition, CD19 negative relapses are another challenge that needs to be tackled. Dr Ghorashian goes on to discuss strategies for dual CAR targeting, in particular CD19CAT and CD22 CAR T-cells. This interview took place during the 3rd European CAR T-cell Meeting.

Blinatumomab – VJRegenMed

CAR-T vs. BiTEs in B-cell malignancies

The challenges of CAR T-cell therapy for pediatric B-ALL