CTX110 – VJRegenMed https://mirror.vjregenmed.com The Video Journal of Regenerative Medicine Mon, 22 Apr 2024 12:45:24 +0000 en-US hourly 1 https://wordpress.org/?v=6.5.2 https://d2xz56kaqxj8if.cloudfront.net/wp-content/uploads/2023/09/12102509/VJR-Favicon.png CTX110 – VJRegenMed https://mirror.vjregenmed.com 32 32 CARBON trial: investigating CTX110 allogeneic CRISPR-Cas9–engineered CAR-Ts in R/R LBCL https://mirror.vjregenmed.com/video/pg9ze6fvjva-carbon-trial-investigating-ctx110-allogeneic-crispr-cas9-engineered-car-ts-in-rr-lbcl/ Thu, 26 Jan 2023 12:11:30 +0000 https://mirror.vjregenmed.com/video/pg9ze6fvjva-carbon-trial-investigating-ctx110-allogeneic-crispr-cas9-engineered-car-ts-in-rr-lbcl/ Constantine Tam, MBBS (Hons), MD, FRACP, FRCPA, Peter MacCallum Cancer Centre, St. Vincent’s Hospital, University of Melbourne, Melbourne, Australia, reports results from the CARBON Phase I dose-escalation study (NCT04035434), testing the safety and efficacy of a novel allogeneic CRISPR-Cas9-engineered CAR-T product, CTX110, in heavily pre-treated patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). The study reported that the CAR-Ts showed clinical activity with the ability to expand in the body, and a low risk of graft-versus-host disease (GvHD). This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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