LMY-920 – VJRegenMed

Advances in allogeneic γδ T cells

Simon Ng — Tue, 22 Feb 2022 15:00:55 +0000

Jeff Liter, MBA, Luminary Therapeutics, Minneapolis, MN, discusses the development of allogeneic gamma delta (γδ) T cells. Whilst there has previously been a focus on autologous therapies such as LMY-920, a B-cell activating factor (BAFF)-directed CAR-T therapy, current attention is directed towards allogeneic therapies. The emergence of γδ T cells have been beneficial as they do not cause graft versus host disease (GvHD) and are already HLA matched between donor and patient. Dr Liter additionally highlights a proprietary Tc Buster Transposon system that enables expansion of the Vδ1 and Vδ2 subtypes of γδ T cells. This interview took place at Advanced Therapies Week 2022.

LMY-920 in non-Hodgkin lymphoma

Simon Ng — Mon, 14 Feb 2022 17:40:19 +0000

Patients with B-cell non-Hodgkin lymphoma (NHL) can progress on current anti-CD19 chimeric antigen receptor (CAR) T-cell therapies due to antigen escape. Jeff Liter, MBA, Luminary Therapeutics, Minneapolis, MN, provides an overview of LMY-920, a B-cell activating factor (BAFF)-directed CAR-T therapy, which consists of three different antigens on the CAR T-cell. The three markers prevents antigen escape and the therapy additionally contains no foreign linkers, reducing immunogenicity. An Investigational New Drug Application (IND) will be imminently filed for LMY-920, with the therapy aiming to target NHL and mantle cell lymphoma (MCL). This interview took place at Advanced Therapies Week 2022.