CAR T-cells in adult ALL

Marta Palhas — Fri, 26 Feb 2021 14:08:28 +0000

CD19-directed CAR T-cells have been approved for use in children and young adults up to the age of 25 years with acute lymphoblastic leukemia (ALL). Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, outlines the use of CAR T-cells in adult ALL. Several prognostic factors for CAR-T therapy’s success have been identified, including platelet count before CAR-T infusion, lactate dehydrogenase (LDH) level, and mutated p53. Additionally, Prof. Nagler discusses if CAR T-cells are the definitive therapy for ALL or a pathway to allogeneic transplant. Finally, Prof. Nagler shares new approaches for CAR T-cells in ALL, including CD22-directed CAR T-cells, sequential administration of CD19 and CD22 CAR T-cells, bispecific CARs, and allogeneic CAR T-cells. This interview took place during the 3rd European CAR T-cell Meeting.

Novel strategies to optimize CAR T-cell therapy

Marta Palhas — Fri, 26 Feb 2021 14:08:27 +0000

Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, discusses approaches to optimize CAR T-cell therapy. CAR T-cell therapies have achieved impressive outcomes in hematological malignancies. However, setbacks such as limited CAR T-cell persistence after infusion, high relapse rates, resistance, and toxicities continue to be experienced. Prof. Nagler outlines novel strategies to improve CAR T-cell function, including novel constructs, new targets, bispecific CAR-T cells, and allogeneic CAR-Ts. This interview took place during the 3rd European CAR T-cell Meeting.

Arnon Nagler – VJRegenMed

CAR T-cells in adult ALL

Novel strategies to optimize CAR T-cell therapy