Ipsita Roy – VJRegenMed

Nerve regeneration with polyhydroxyalkanoate-based conduits

Simon Ng — Thu, 20 Jan 2022 17:55:00 +0000

Ipsita Roy, PhD, University of Sheffield, Sheffield, UK, provides an overview of polyhydroxyalkanoate (PHA)-based nerve guidance conduits for peripheral nerve regeneration. Changes in the PHA formulation resulted in the creation of a stiff, but elastic tubular structure and in vivo studies demonstrated that the scaffold regenerated damaged nerves after a 10 week period as effectively as autologously transplanted nerves. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

The advantages of polyhydroxyalkanoate-based scaffolds

Simon Ng — Thu, 20 Jan 2022 17:54:59 +0000

Ipsita Roy, PhD, University of Sheffield, Sheffield, UK, comments on the benefits of using polyhydroxyalkanoate (PHA) over alternative materials as scaffolds in regenerative medicine. Compared to other biocompatible polymers such as polycaprolactone (PCL) and poly(L-lactide) (PLLA), PHA is a sustainable polymer and produces natural metabolites when it degrades, unlike PLLA which degrades to lactic acid. PHA is additionally more stable than hydrogels such as alginate, and can be manipulated to have different properties, allowing it to have multiple functions. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Polyhydroxyalkanoate-based scaffolds for engineered cardiac tissue

Simon Ng — Mon, 17 Jan 2022 13:05:32 +0000

The formation of scar tissue after a myocardial infarction decreases functionality of the heart, and heart transplantation is often required as a result. Ipsita Roy, PhD, University of Sheffield, Sheffield, UK, discusses the role of polyhydroxyalkanoates (PHAs) in cardiac tissue engineering. Patches made from PHA seeded with cardiac tissue derived from induced pluripotent stem cells (iSPCs) can surpass the need for transplantation by regenerating healthy tissue in the heart. PHAs are biocompatible and have demonstrated promising efficacy as a drug delivery system. Prof. Roy also highlights the development of multi-material patches with the addition of alginate. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Medical applications of polyhydroxyalkanoates

Simon Ng — Mon, 17 Jan 2022 13:05:29 +0000

Ipsita Roy, PhD, University of Sheffield, Sheffield, UK, describes the clinical uses of polyhydroxyalkanoates (PHAs). The polymer has shown to be useful in engineering a variety of tissues including bone, cartilage, pancreas, and kidney, as well as in drug delivery. PHA additionally has potential in delivering vaccines, as it can hold mRNA, which may prove beneficial in combating the COVID-19 pandemic. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).