Ngan Huang – VJRegenMed

Spatially patterned scaffolds in vascular regeneration

Simon Ng — Tue, 21 Dec 2021 15:01:17 +0000

Ngan Huang, PhD, Stanford University, Stanford, CA, discusses how vascular systems can be regenerated with collagen scaffolds. Extruded collagen scaffolds can be stacked on top of each other to support vascularization in muscle cells, and in myocytes with the spatially aligned scaffold, longer myotubes were formed, which enabled more successful and organized muscle regeneration. Scaffold orientation additionally influenced muscle growth by stimulating the release of pro-angiogenic growth factors in endothelial cells. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Future directions in cardiac tissue engineering

Simon Ng — Tue, 21 Dec 2021 15:01:15 +0000

Ngan Huang, PhD, Stanford University, Stanford, CA, provides an overview of what the next steps are in the field of cardiac tissue engineering. Innovations including the use of induced pluripotent stem cells (iSPCs) as a cell source and 3D printing will enable the development of complex structures on a larger scale. Dr Huang additionally highlights computational biology and single-cell RNA sequencing as technologies that will provide researchers a better understanding of tissue engineering at a cellular level. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Delivering cell therapies in abdominal aortic aneurysms

Simon Ng — Tue, 21 Dec 2021 15:01:14 +0000

Ngan Huang, PhD, Stanford University, Stanford, CA, describes the development of novel systems to deliver stem cells to the aorta in patients with an abdominal aortic aneurysm (AAA). AAA can be life-threatening in patients and delivering therapies to the area remain a challenge due to the fragility of the aorta. Stem cells enable the repair of damaged smooth muscle cells and the production of elastin, and reinforced scaffolds can safely deliver the stem cells to the aorta via the adventitia, the outermost layer of the vessel. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).