Suradip Das – VJRegenMed

Treating volumetric muscle loss with tissue-engineered products

Simon Ng — Mon, 17 Jan 2022 18:10:29 +0000

Volumetric muscle loss (VML) is the loss of skeletal muscle and associated tissue and may result in amputation. Suradip Das, PhD, University of Pennsylvania, Philadelphia, PA, describes the role of neurons in providing tissue-engineered therapies for volumetric muscle loss (VML). Aligned nanofiber sheets cultured with myocytes and motor neurons have demonstrated efficacy in mouse models. Innervation of the engineered tissue enhanced muscle stem cell proliferation and further research is required to successfully implement the findings on a larger scale. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Accelerating regenerative therapies for volumetric muscle loss

Simon Ng — Mon, 17 Jan 2022 18:10:28 +0000

Suradip Das, PhD, University of Pennsylvania, Philadelphia, PA, discusses issues relating to tissue-engineered treatments for volumetric muscle loss (VML). Finding the optimal conditions for co-culturing myocytes and motor neurons, which are both necessary for muscle growth, is an important consideration, as well as developing strategies to have animal models with similar levels of VML. Dr Das additionally comments on the potential use of induced pluripotent stem cells, and clinically relevant delayed repair models in an in vivo setting. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).