Yan Zhang – VJRegenMed

The Tapestri Platform: a single-cell multi-omics system

Simon Ng — Thu, 25 Nov 2021 14:55:40 +0000

Yan Zhang, PhD, Mission Bio, San Francisco, CA, provides an overview of the Tapestri Platform, a system that incorporates single-cell multi-omics technology, which enables the monitoring of intracellular changes within a single cell. A two-step microfluidic workflow simultaneously isolates and analyzes DNA and proteins in single cells, followed by cell barcoding and targeted multiplex PCR. Dr Zhang additionally highlights the importance of focusing on DNA and proteins in monitoring changes at a single-cell level, as opposed to RNA. This interview took place at Meeting on the Mesa 2021.

Applications of single-cell multi-omics analysis

Simon Ng — Thu, 25 Nov 2021 14:55:39 +0000

Yan Zhang, PhD, Mission Bio, San Francisco, CA, describes the capabilities of the Tapestri Platform, which utilizes single-cell multi-omics technology. Tapestri can accurately measure the efficacy and safety of cell and gene therapies by monitoring genomic and protein changes at a single-cell level. The platform can additionally elucidate mechanisms of relapse or resistance to cancer therapies. Resistance can occur due to mutations or changes in the tumor microenvironment, and the platform enables analysis of resistant cells to gain insight into disease progression. This interview took place at Meeting on the Mesa 2021.

Utilizing single-cell multi-omics throughout the product pipeline

Simon Ng — Thu, 25 Nov 2021 14:55:38 +0000

Yan Zhang, PhD, Mission Bio, San Francisco, CA, discusses how DNA and protein single-cell multi-omics can be applied throughout the development pipeline of advanced therapies. The Tapestri Platform can optimize the design of therapies by expediting the target validation process. The platform can additionally monitor therapeutic efficacy in various animal models in the preclinical stages, as well as humans in clinical trials. This interview took place at Meeting on the Mesa 2021.