Huntington’s Disease – VJRegenMed https://mirror.vjregenmed.com The Video Journal of Regenerative Medicine Tue, 25 Jan 2022 12:51:03 +0000 en-US hourly 1 https://wordpress.org/?v=6.5.2 https://d2xz56kaqxj8if.cloudfront.net/wp-content/uploads/2023/09/12102509/VJR-Favicon.png Huntington’s Disease – VJRegenMed https://mirror.vjregenmed.com 32 32 Expanding the repertoire of CRISPR-based genomic editors https://mirror.vjregenmed.com/video/ewynfc-0pdw-expanding-the-repertoire-of-crispr-based-genomic-editors/ Thu, 04 Nov 2021 18:04:42 +0000 http://13.40.107.223/video/ewynfc-0pdw-expanding-the-repertoire-of-crispr-based-genomic-editors/ Devyn Smith, PhD, Arbor Biotechnologies, Cambridge, MA, provides a brief overview of the tailored nuclease therapies developed at Arbor Biotechnologies. Multiple nucleases have been discovered that are superior to the original Cas9 endonuclease and a portfolio of nucleases, which have been modified to improve efficacy, has been developed. Certain nucleases can be adapted for specific diseases such as Huntington’s disease, a trinucleotide repeat disorder, by having the optimal protospacer adjacent motif (PAM). This interview took place at Meeting on the Mesa 2021.

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