Organoids – VJRegenMed

Advances in organ bioengineering

admin_vjr_user — Tue, 04 Jan 2022 17:52:19 +0000

Paolo De Coppi, MD, PhD, FMedSci, UCL Great Ormond Street Institute of Child Health & NIHR Biomedical Research Centre, London, UK, provides an overview of the current landscape of bioengineering for organ replacement and some of the key considerations during the development of tissue-engineered organs, including the types of cell and polymers used. He notes that for the regeneration of simple tissues, autologous somatic cells may be sufficient, however, for more complex organs, pluripotent stem cells would likely be required, which would require immunosuppression upon implantation in order to avoid tissue rejection. Dr De Coppi also describes ongoing research into the use of biliary organoids for the repair of the damaged liver. This interview took place during the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021.

Driving the translation of intestinal tissue engineering

admin_vjr_user — Tue, 04 Jan 2022 17:52:17 +0000

Paolo De Coppi, MD, PhD, FMedSci, UCL Great Ormond Street Institute of Child Health & NIHR Biomedical Research Centre, London, UK, describes ongoing research aiming to address challenges facing the development of tissue engineering strategies for the treatment of intestinal failure and their translation into patients. While it has been demonstrated that organoid technology can used to replace the intestinal mucosa, the development of Good Manufacturing Practice (GMP)-compliant methods for organoid expansion are required before human transplantation. Given the organ complexity of the intestine, instead of engineering the entire intestine, ongoing research is focused on engineering a functional small intestine mucosa which could be transplanted into the large intestine. This interview took place during the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021.

Elucidating mechanisms of hearing loss with iSPCs

Simon Ng — Tue, 04 Jan 2022 13:03:22 +0000

Brigitte Malgrange, Pharm.D, PhD, University of Liège, Liège, Belgium, describes ongoing research to develop organoids and bioassays for researching hereditary hearing loss. Over 100 genes are implicated in hereditary hearing loss and sourcing induced pluripotent stem cells (iSPCs) derived from fibroblasts are important to determine the mechanisms of the disease. Dr Malgrange additionally highlights the possibility of developing regenerative therapies as a result of the aforementioned research conducted. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Applications of brain organoids in neurology

Simon Ng — Wed, 22 Dec 2021 10:32:52 +0000

Ira Espuny-Camacho, PhD, University of Liège, Liège, Belgium, describes the development of brain organoids as disease models. Organoids formed from hematopoietic stem cells (HSCs) can mimic the 3D architecture of the brain and can provide an insight into cortical development without any external stimuli. Using brain organoids can subsequently serve as models for neurodevelopmental and neurodegenerative diseases. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Developing the bioartificial pancreas

admin_vjr_user — Thu, 19 Aug 2021 11:47:29 +0000

Ekaterine Berishvili, MD, PhD, University of Geneva, Geneva, Switzerland, describes ongoing research towards the development of the bioartificial pancreas for the treatment of type I diabetes, through the use of a range of tissue engineering, immune modulation and genome editing strategies. Given their immunomodulatory characteristics, he discusses strategies under investigation that utilize placental derivatives, as well as the development of placenta extracellular matrix-based biomaterials. The generation and transplantation of insulin-secreting organoids into a diabetic mouse model demonstrated successful engraftment, vascularization and therapeutic benefit. This interview took place during the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021.

Renin producing human kidney organoids

admin_vjr_user — Wed, 19 Aug 2020 16:20:19 +0000

Anushka Shankar, MD, MSc, of Erasmus University Rotterdam, Rotterdam, the Netherlands, discusses the development of human kidney organoids from stem cells, that can restore the endocrine system, including renin production. Furthermore, Dr. Shankar outlines the next steps in research, including determining how physiological interactions may affect renin production. This interview was recorded via an online conference call with The Video Journal of Regenerative Medicine (VJRegenMed).

Next steps in kidney organoid development

admin_vjr_user — Wed, 19 Aug 2020 16:20:19 +0000

Anushka Shankar, MD, MSc, of Erasmus University Rotterdam, Rotterdam, the Netherlands, outlines the next steps in developing functional kidney organoids including vascularization, and furthermore highlights the importance of safety analysis before these novel therapies can be used in routine clinical practice. This interview was recorded via an online conference call with The Video Journal of Regenerative Medicine (VJRegenMed).