Orthobiologics – VJRegenMed

The role of bioactive ceramics in vascularized bone regeneration

Simon Ng — Mon, 17 Jan 2022 18:10:26 +0000

Jiao Jiao Li, PhD, University of Technology Sydney, Sydney, Australia, discusses research on regenerating vascularized bone with bioactive ceramics. Current challenges in the field include developing load-bearing scaffolds that can interact with bone cells and are porous. Therapies that encourage vascularization in the bone are necessary due to the metabolic demands of bones, and advances in 3D bioprinting have enabled research into bioactive ceramics. Nanoparticles additionally represent encouraging solutions to musculoskeletal conditions including osteoarthritis. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Healing diabetic ulcers with nanoclays

Simon Ng — Mon, 17 Jan 2022 18:10:25 +0000

Jonathan Dawson, PhD, University of Southampton, Southampton, UK, gives an overview of utilizing nanoclays in treating diabetic foot ulcers. Nanoclays can concentrate proteins from the surrounding area, and administration of vascular endothelial growth factor (VEGF) in the wound area has shown to stimulate angiogenesis and thus enhance wound repair in patients with diabetes. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

The osteogenic properties of nanoclays

Simon Ng — Mon, 17 Jan 2022 18:10:23 +0000

Jonathan Dawson, PhD, University of Southampton, Southampton, UK, discusses how the properties nanoclays can promote bone regeneration. Magnesium, lithium, and silicate ions released as a result of nanoclay degeneration have proven to stimulate osteogenic pathways in vivo, and nanoclays can modulate macrophage activity, further enhancing bone regeneration. Additional in vivo studies have demonstrated the safety of nanoclays, which do not aggregate in blood or tissue and instead are excreted via the urine. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Utilizing bioglass as a drug delivery system

Simon Ng — Mon, 17 Jan 2022 13:05:30 +0000

Julian Jones, PhD, Imperial College London, London, UK, describes the applications of bioglass in osteoporosis and cancer. Nanoparticles including bioglass release ions and can be directed to specific tissue, making them a suitable drug delivery system. Bioglass containing strontium ranelate have shown to safely mitigate the effects of osteoporosis by maintaining osteoblast activity, and when containing zinc, can effectively kill cancer cells without harming healthy tissue. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Studying the bone-tendon interface with tissue engineering

Simon Ng — Thu, 13 Jan 2022 16:36:15 +0000

Bones and tissues are connected via the bone-tendon interface, and when ruptured, is replaced by weaker scar tissue. Ilze Donderwinkel, Monash University, Melbourne, Australia, discusses strategies to research mechanisms of regenerating the bone-tendon interface via models based on tissue engineered hydrogel blocks. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Future applications of BMP-2

Simon Ng — Thu, 13 Jan 2022 16:36:08 +0000

Bone morphogenetic protein 2 (BMP-2) is a growth factor currently used for spinal fusion in patients. Jonathan Dawson, PhD, University of Southampton, Southampton, UK, comments on potential applications of BMP-2 beyond fusing spinal discs in the lower spine. Due to high concentrations of BMP-2 required, it is only administered in the lower spine. Dr Dawson discusses research being carried out to safely use BMP-2 in other areas of the spine and in an outpatient setting. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Enhanced bioglass for cartilage regeneration

Simon Ng — Tue, 11 Jan 2022 17:26:15 +0000

Julian Jones, PhD, Imperial College London, London, UK, discusses the development of bouncy bioglass for articular cartilage repair. Current cartilage regeneration involving microfracture surgery only produces scar-like cartilage and 3D-printed bouncy bioglass of a certain pore channel size enables production of articular cartilage. Whilst initial in vivo studies have demonstrated favorable cartilage growth in animal models, further research is required to elucidate the exact composition of type I and type II collagen in the cartilage. This interview took place at 6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

What to expect in the field of orthobiologics

Simon Ng — Tue, 11 Jan 2022 17:26:13 +0000

Julian Jones, PhD, Imperial College London, London, UK, provides an overview of advancements in bone and cartilage regeneration. Hydrogel scaffolds have demonstrated to aid promising cartilage regeneration, with its high water content mimicking the extracellular matrix. Within the field of bone regeneration, the development of load-bearing materials and scaffolds remain an unmet need and Prof. Jones additionally highlights progress within skin regeneration, which can now potentially treat severe injuries. This interview took place at 6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Clinical translation of regenerative nanoclays

Simon Ng — Mon, 10 Jan 2022 15:38:50 +0000

Jonathan Dawson, PhD, University of Southampton, Southampton, UK, provides an overview of barriers to developing regenerative nanoclays for the clinic. Refining the manufacturing process so that the final product adheres to good manufacturing process (GMP) standards and is clinical-grade is important. As the nanoclay additionally contains bone morphogenetic protein 2 (BMP-2), classification of the product may present challenges to regulatory authorities, and varying regulatory requirements across different countries will also present potential barriers. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).

Regenerative nanoclays in bone regeneration

Simon Ng — Mon, 10 Jan 2022 15:38:48 +0000

Jonathan Dawson, PhD, University of Southampton, Southampton, UK, describes the mechanism of action of regenerative nanoclays. Nanoclays have reversible gel-like properties when in water and can attract proteins with their charge. These properties enable nanoclays to be used in bone growth, as growth factors including bone morphogenetic protein 2 (BMP-2) can aggregate within the nanoclay and be delivered to a localized area, reducing the dosage needed. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).